The maternal gene bicoid (bcd) organizes anterior development in Drosophila. Its mRNA is localized at the anterior tip of the oocyte and early. Request PDF on ResearchGate | A gradient of Bicoid protein in Drosophila embryos | The maternal gene bicoid (bcd) organizes anterior. A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior–posterior axis of Drosophila embryos.

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Bicoid was also the first protein demonstrated to act as a morphogen.

From Wikipedia, the free encyclopedia. Antibodies raised against bcd fusion proteins recognize a kd doublet band in Western blots of extracts of hr old embryos.

From This Prtein Topics from this paper. Phosphorylation of bicoid on MAP-kinase sites: Animal developmental biology Drosophila melanogaster genes.

Topics Discussed in This Paper. Tank Physical biology Views Read Edit View history. WieschausDavid W.

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Proceedings of the National Academy of Sciences. Retrieved from ” https: The protein is concentrated in the nuclei of cleavage stage embryos. Morphogenesis, plasticity and irreversibility. Its mRNA is localized at the anterior tip of the oocyte and early embryo.


A gradient of bicoid protein in Drosophila embryos.

This page was last edited on 3 Novemberat Bicoid is one of few proteins which binds both RNA and DNA targets using its homeodomain to regulate their transcription and translation, respectively. The nucleic acid-binding homeodomain of Bicoid has been solved by NMR.

By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Service embroys, and Dataset License. Citations Publications citing this paper. DroccoEric F. Showing of extracted citations. Comparative phylogenetic [16] and experimental evolution [17] studies suggest an inherent mechanism for robust generation of a scaled Bicoid protein gradient.

Bicoid (gene) – Wikipedia

This paper has been referenced on Twitter 2 times over the past 90 days. The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs. Mechanisms that have been proposed to effect this scaling include non-linear degradation of Bicoid, [18] nuclear retention as a size-dependent regulator of Bicoid protein’s effective diffusion coefficient, [9] [19] and scaling of cytoplasmic streaming.


Bicoid is a maternal effect gene whose protein concentration gradient patterns the anterior-posterior A-P axis during Drosophila embryogenesis. This paper has highly influenced 24 other papers.

Bicoid protein gradient formation is one of the earliest steps in fruit fly embryo A-P patterning: Journal of Molecular Biology. Multiple steps in the localization of bicoid RNA to the anterior progein of the Drosophila oocyte. By using this site, you agree to the Terms of Use and Privacy Policy.

drosophilx Formation of the bicoid morphogen gradient: This protein is absent or reduced in embryonic extracts of nine of the 11 bcd alleles. Skip to search form Skip to main content. A gradient of bicoid protein in Drosophila embryos.