This review presents an analysis of the current data on the structural and functional organization and biological significance of epithelial cell rests of Malassez. Definition: The epithelial cell rests of Malasse are discrete clusters of residual cells from Hertwig’s epithelial root sheath (HERS) that didn’t. The authors performed a PubMed search on the term “epithelial rests” alone or in combination with “Malassez.” Relevant articles were categorized into primary.

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ERM distributed around the tooth root, forming something like a fishing net. By using this site, you agree to the Terms of Use and Privacy Policy.

[Epithelial cell rests of Malassez: tissue, cell, and molecular biology].

Epithelial cell rests of Malassez bind epidermal growth factor intensely. Although some functions have been assigned to ERM by several authors, none has been supported by solid scientific evidence. In this procedure, epithelial cells associated with ERM modify their distribution and express BMP-2, osteopontin and ameloblastin.

Dentition Teething Tooth eruption. Thus, this review aims at demystifying the idea that ERM constitute epitbelial cells of odontogenesis with malasez defined function, but rather represent cells with responsibilities in maintaining periodontal space and orthodontic movement. Wallace JA, Vergona K. However, over the last 50 years, studies have gradually revealed the participation of ERM in the synthesis of mediators linked to the maintenance of periodontal homeostasis.

Production of amelogenin by enamel epithelium of Hertwig’s root sheath. The epithelial cell rests of Malassez and the genesis of the dental fpithelial. The histochemical demonstration of epitheljal oxidative enzymes and glycogen in the mapassez cell rests of Malassez. Mechanisms of tooth eruption and orthodontic tooth movement.

Author information Article notes Copyright and License information Disclaimer. Detection of lysosomal enzymes derived from pig periodontal ligament fibroblasts and their ability to digest collagen fibrils and proteoglycan. In addition, paracrine signalling through the secretion of mediators of bone resorption would not take place, impacting on the process of bone remodelling around the tooth and leading to the tooth assuming the traits of ankylosis.


Such evidence created possibilities for dests investigations. Gutknecht comments, “With more than 25 years’ laser research experience, I am excited to share my dental laser knowledge with leading South African dentists, and in turn, your public.

The bone morphogenetic proteins, especially BMP-2, as well as bone matrix proteins, act in regulating osteogenesis, with an initial rise in the dental follicle. Tuesday 24 May Evolution and development of Hertwig’s epithelial root sheath. When properly executed, the orthodontic movement is able to stimulate the secretory power of these cells, which prevents the recurrence of ankylosis. Skip to search form Skip to main content. The ERM represent the only odontogenic epithelial structure able to persist in the periodontal ligament peithelial adulthood, as epitgelial is the only structure able to persist in situations in which the periodontal ligament tissue is affected.

The significance of epithelial rests of Malassez in the periodontal ligament. From Wikipedia, the free encyclopedia. A literature search was performed on 17th February,using the term “epithelial cell rests of Malassez” which produced results.

Epithelial cell rests of Malassez contain unique stem cell populations capable of undergoing epithelial-mesenchymal transition. This role is contrary spithelial the events resulting from the induced orthodontic tooth movement. Immunohistochemical characteristics of epithelial cell rests epitthelial Malassez during cementum repair. Reeve and Wentz 16 determined the frequency of epithelial rests in patients aged years, classifying different ERM types and locations on the periodontal ligament.

They are named after Louis-Charles Malassez — who described them. Expression of amelin and amelogenin in epithelial root sheath remnants of fully formed rat molars.

Tooth development Epithelial cells. The significance of epithelial rests of Malassez in the periodontal ligament. Reviews resta this topic are infrequent in the dental literature and the notable advances regarding the cytokine profile of the epithelial cell rests of Malassez and their autocrine and paracrine roles in the periodontal tissues make it opportune to review their physiological roles in maintaining periodontal health.


Association of orthodontic force system and root resorption A systematic review. Angle Orthodont ; 78 4: How to cite this article.

Services on Demand Journal. Stem Cells ; The prevalence, morphology, and distribution of epithelial eoithelial in the human periodontal ligament. In vitro characterization of the cytokine profile of the epithelial cell rests of Malassez. The maintenance of this balance by REM allows for maintenance of the periodontal ligament space 4546 and prevents the occurrence of dentoalveolar ankylosis, contributing to reorganization of the periodontal ligament during orthodontic tooth movement and resorption.

This promotes the inclusion of new collagen fibres at the damaged cementoblastic surface, induced by ERM, allowing the root surface to regenerate and return to its normal state.

[Epithelial cell rests of Malassez: tissue, cell, and molecular biology].

Expression and role of epidermal growth factor receptors during differentiation of cementoblasts, osteoblasts, and periodontal ligament fibroblasts in the rat. From the release of substances and differentiation of its epithelial cells, the remaining ERM play an important role in the formation and repair of cementum, particularly in the differentiation of cementoblasts with mesenchymal origin, preferably through the direct transformation of epithelial cells to cementoblasts.

Find articles by David Normando. This result suggests the participation of ERM in the regeneration and repair of cementum.

These resistant structures are extremely important for maintaining homeostasis.